Link to MS13-093: http://support.microsoft.com/kb/2875783/en-us

I am running Windows 8 with all the latest patches. Well, WAS running all the latest patches up until this one breaks my keyboard and mouse. After I install this update, I reboot and when windows comes back up the the login screen, neither the keyboard or mouse work.

I have tried rebooting. I have tried unplugging and plugging them back in. I have tried leaving them unplugged as I boot up, and then plug them in once Windows starts. I have tried a different keyboard and a different mouse. I also dual-boot into Ubuntu, which works fine with the keyboard and mouse.

I don't know what it is about this update, but after I install it, my keyboard and mouse no longer function.

Perform System Restore to an earlier date and check if it helps.
a: Swipe in from the right edge of the screen, and then tap Search.
(If you're using a mouse, point to the upper-right corner of the screen, move the mouse pointer down, and then click Search.)
b: Enter Control Panel in the search box, and tap or click Control Panel.
c: Enter Recovery in the Control Panel search box, and then tap or click Recovery.
d: Tap or click Open System Restore, and then follow the instructions.